Charter Life Sciences





	APT Pharmaceuticals Secures $32 Million in Series B Financing September 30, 2008 XLumena Spots $6M For Ultrasound Devices June 4, 2008 Mirabilis Completes First Human Trial of Non-Invasive Treatment for Uterine Fibroids APRIL 28, 2008 Astellas and CoMentis Sign Agreement to Collaborate on the Research, Development and Commercialization of Beta-Secretase Inhibitors APRIL 25, 2008 EnteroMedics Announces Planned Expansion of EMPOWER Pivotal Study for Obesity to 300 Patients February 26, 2008 KFx Medical Corporation Appoints Matt Meyer as its Vice President Marketing February 20, 2008 EnteroMedics(TM) Announces Nine-Month Clinical Results on Its VBLOC-RF2 Feasibility Study for Obesity Therapy January 8, 2008 EnteroMedics(TM) Announces Pivotal Clinical Study of its VBLOC(TM) Therapy for Obesity January 7, 2008 CoMentis Announces Proof-of-Activity-Data from its Phase I Study of Disease-Modifying Alzheimer’s Disease Therapy January 7, 2008 APT Pharmaceuticals Expands Management Team NOVEMBER 19, 2007 EnteroMedics Announces Initial Public Offering NOVEMBER 14, 2007 APT Pharmaceuticals Closes New $22 Million Funding Round OCTOBER 4, 2007 JDRF Partners with CoMentis for Diabetic Macular Edema Clinical Trial SEPTEMBER 20, 2007 Mirabilis Closes $10.5 Million Series A Extension to Commercialize Non-invasive Treatment of Uterine Fibroids AUGUST 21, 2007 KFx Medical Corporation Closes $10 Million Series B Financing AUGUST 9, 2007 JDRF Partners with CoMentis for Diabetic Macular Edema Clinical Trial JUNE 18, 2007 CoMentis Announces Appointment of Martin Tolar, M.D., Ph.D., as Vice President JUNE 6, 2007 APT Acquires Exclusive Worldwide Rights to Develop and Commercialize Inhalable Cyclosporine to Prevent Lung Transplant Rejection JUNE 5, 2007 Enteromedics Files Registration Statement for Proposed Initial Public Offering MAY 25, 2007 CoMentis Initiates Phase II Clinical Trial for AMD Eye Drop Therapy APRIL 10, 2007 Athenagen Announces Name Change to CoMentis FEBRUARY 10, 2007 Athenagen’s Eye Drop Therapy for AMD is Safe and Well Tolerated in Phase I Study JANUARY 31, 2007 Athenagen Initiates Phase II Clinical Trial in Alzheimer’s Disease DECEMBER 13, 2006 Mirabilis Medica Names Mike Connolly CEO OCTOBER 3, 2006 Athenagen Raises $50 Million in Series B Financing SEPTEMBER 28, 2006 Amaranth Medical Closes $7.5 Million Series A Financing to Advance the Development of Bio-Absorbable Stents SEPTEMBER 26, 2006 Mirabilis Raises $4 Million to Commercialize Non-Invasive Treatment of Uterine Fibroids AUGUST 29, 2006 Athenagen Initiates Clinical Development of its Anti-angiogenic Eye Drop Therapy for AMD AUGUST 21, 2006 Athenagen Completes Merger with Zapaq AUGUST 14, 2006 KFx Medical Corporation Receives 510k Clearance for Knotless Tissue Fixation AUGUST 10, 2006 Athenagen Announces Publication of Results from a Proof-of-Concept Trial of its Novel alpha-7 Nicontinic Receptor Agonist in Schizophrenia JUNE 15, 2006 Athenagen Acquires Osprey Pharmaceutical Company - Adds Clinical-Stage Alzheimer's Drug Candidate to its Pipeline APRIL 13, 2006 Aradigm and APT Pharmaceuticals Initiate Phase 2 Clinical Program of Novel Treatment for Asthma MARCH 23, 2006 Athenagen Adds A. Barr Dolan to its Board of Directors FEBRUARY 22, 2006 Previous News Stories >


	Mirabilis Closes $10.5 Million Series A Extension to Commercialize Non-invasive Treatment of Uterine Fibroids SEATTLE, WA – AUGUST 21, 2007 Mirabilis Medica, a privately-held medical device company, today announced the closing of a $10.5 million extension to its series A financing, which was originally led by Charter Life Sciences and vSpring Capital last year. The series A extension was led by Arboretum Ventures of Ann Arbor MI, and included Split Rock Partners, Dow Venture Capital, and an individual investor. The funding will be used to continue developing and testing its image-guided High Intensity Focused Ultrasound (HIFU) system for treatment of gynecological diseases. Mirabilis? technology is designed to allow a physician to destroy pathological tissue deep inside the body without damage to intervening tissue, and to monitor effects with real-time ultrasound imaging ? all in a low-cost office setting. While this approach could address a variety of conditions, Mirabilis will initially target uterine fibroids, which cause cramps and bleeding in 25% of women of reproductive age (an estimated 16 million U.S. women). Fibroids account for one-third of the 600,000 annual U.S. hysterectomies ? a major invasive surgery with many side effects. It is estimated that one in three women have a hysterectomy by age 60. Yet most fibroid sufferers ? unwilling to submit to such a drastic procedure -- remain untreated. ?Arboretum is thrilled to support this endeavor,? said Jan Garfinkle, managing director of Arboretum Ventures. ?Fibroids are a huge unaddressed health issue for women, and we believe Mirabilis? talented team is developing a break-through solution.? ?Our new investors bring a wealth of experience in commercializing medical devices, and we are gratified that they share our vision and confidence in the Mirabilis team,? said CEO Mike Connolly. About Mirabilis Medica The mission of Mirabilis (?mir-RA-bi-lis?) is to develop non-invasive solutions for conditions that have traditionally required invasive surgery. The company was founded in 2004 by Michael Lau, M.D., FACS, FACOG; Alexander Lebedev; and Shahram Vaezy, Ph.D. Dr. Vaezy was lead inventor of the company?s patented technology, which was initially developed at University of Washington and exclusively licensed to Mirabilis. For more information, see www.mirabilismedica.com For more information, see www.mirabilismedica.com CONTACT: Alexander Lebedev Director of Operations, (206) 313-4678 alebedev@mirabilismedica.com