CLS (CHARTER LIFE SCIENCES) is an early stage life sciences venture capital investor.

CLS makes initial portfolio company investments in life sciences companies that are seeking capital to obtain initial proof-of-efficacy of their products (see Investment Criteria), and we continue to support our successful portfolio companies with follow on investments until they are acquired or go public.

Our team is led by four Managing Partners who have worked together to create and build life sciences companies for over twenty years. Our team brings extensive scientific, clinical, regulatory, operational and finance experience to each of our portfolio companies.

We play an active role in helping entrepreneurs build successful companies. Our time, energy and passion is devoted to building early stage life sciences opportunities. As a result, your company will be compared only against other early stage opportunities. So, at CLS, your early stage biotech medical device or health care information technology company will not be compared against a PIPE investment in an undervalued Phase III company, as an example. Early stage is what we do, and all we do.


We understand that early stage companies do not have all the answers and do not have all the data. We understand that many basic questions need investment capital to answer, and we understand that development plans and milestones are subject to lots of uncertainty and change. We understand what it takes to build a management team from scratch, and we invest in companies with little or no existing management. In short, we understand what it is to be an early stage entrepreneur, because each of us has been one.

Please look carefully at our investment criteria and our team, and if we are the type of partner that you would like to work with, please contact us.

In the News

KFx announced that it has been awarded a third patent (US 9,414,835 (‘835)) for self-punching or self-tapping orthopedic anchors that eliminate the need to drill a hole prior to insertion. US (‘835) is part of the family of patents that are the subject of KFx’s pending patent infringement suit against Arthrex, a Naples, Florida based company. In April 2015 KFx announced that the United States Court of Appeals for the Federal Circuit reaffirmed their ruling upholding a judgment of the United States District Court for the Southern District of California that Arthrex infringed three valid KFx patents for double-row rotator cuff [more]
EnteroMedics Inc. (NASDAQ: ETRM), the developer of medical devices using neuroblocking technology to treat obesity, metabolic diseases and other gastrointestinal disorders, today announced clinical success at the Bariatric Center at Sky Ridge Medical Center in Colorado, a vBloc Institute partner, where several vBloc procedures have been performed to date by Frank H. Chae, MD, FACS, Chief Surgeon and Head of the Bariatric Center at Sky Ridge Medical Center. vBloc Institute partners are facilities that have integrated vBloc Therapy and vBloc Achieve into their practices. "The weight loss observed in my vBloc patients is trending greater than reported in the vBloc [more]